“Between 1987 and 1988 our research group made a couple of interesting findings. First, we discovered that vascular
endothelial cells are able to generate nitric oxide gas (NO)1, thus explaining the actions of the ‘endothelium-derived
relaxing factor’ that had been described some seven years earlier2. And subsequently we found that NO was
synthesized directly from the aminoacid L-arginine3. Here I present an overview of the new understanding that NO
has brought to physiology and pathophysiology, with particular emphasis on the therapeutic possibilities that
have arisen as a consequence.”
Moncada S. Nitric oxide: discovery and impact on clinical medicine. J R Soc Med. 1999;92:164–9.[PubMed]

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Nitric oxide: discovery and impact on clinical medicine